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KMID : 0980220080080020113
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Journal of the Korean Dental Society of Anesthesiology
2008 Volume.8 No. 2 p.113 ~ p.117
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Comparison of the Use of Midazolam only with Midazolam Combined with Fentanyl or Propofol in IV sedation
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Lee Dong-Hyun
Kim Jae-Won
Lee Sang-Jun
Kim Jae-Hyun
Jang Tae-Hwa
An Sang-Hun
Jang Heon-Su
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Abstract
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Background: The purpose of this study was to compare the use of midazolam only with midazolam with fentanyl or propofol in IV sedation.
Methods: 24 cases were divided to midazolam group (M group), midazolam + fentanyl group (MF group), midazolam + propofol group (MP group) and midazolam + fentanyl + propofol group (MFP group). In M group, 2 ml midazolam was injected at first, than at 2 minutes interval 1-2 ml injected continuously depending on the level of sedation. In MP, MFP groups, propofol was injected at the speed of 15-20 ml/hr by infusion pump. In this study, the sedation level was evaluated by using OAA/S scale. In each groups, the recovery time was measured until OAA/S scale score level was 5, and pre and postoperative blood pressure change was measured. Each group’s data was statistically analyzed using one-way ANOVA. If significant statistical difference were observed, Dunnet test was performed, and control group was M group.
Results: Pre and postoperative blood pressure change were not represent significant statistical difference in 4 groups (P value = 0.679 [systolic], P value = 0.206 [diastolic]). But recovery time were represent significant statistical difference (M group: 35.6, MF group: 32.5, MP group: 17.9, MFP group: 19.6 [P value = 0.002]). The result of Dunnet test on recovery time showed significant statistical difference on MF, MFP group when M group was control group. In MFP group, sedation was increased by using supplemental fentanyl, and postoperative pain control was dominant.
Conclusion: To achieve the effect of anxiolysis, analgesia, amnesia effectively, and short recovery time, MFP group is mostly recommended.
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KEYWORD
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Conscious sedation, Midazolam, Fentanyl, Propofol
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